| COVID | Moneypox |
| RNA virus | DNA virus |
| 100nm diameter | 220-450nm diameter|
| fast-evolving | slow-evolving |
| R0* of 8.2 | R0 of 1.4-1.8 (currently) |
| Respiratory | Skin-contact |
| 3-5 day incubation | 7-21 day incubation |

*R0 = infection rate